It is difficult to see why an inert substance must be prescribed, but nevertheless, this is the situation in the US. Betahistine can also be easily obtained through US compounding pharmacies, with a prescription. Treatment with Selegiline alone did not affect microcirculation significantly." Availability and orderingĪt the time of this update (2021), we generally just put the order into a mail-order compounding pharmacy. In one guinea pig, the increase was 104.6%. 001) in guinea pigs treated with low dose betahistine combined with selegiline by up to 58.3 ± 38.7% above baseline over a period of up to 11 minutes. In fact, they noted "Cochlear microcirculation increased significantly (P <. Kloos et al (2022) recently reported that in animals, betahistine and selegiline increases cochlear blood flow. One would also wonder if this combination might allow one to get the (sometimes) positive effect of betahistine to reduce weight. Seligiline is usually covered by prescription programs in the US. This strategy might allow one to use much lower doses of betahistine, and perhaps save money on betahistine prescriptions (Strupp reduced the dose by a factor of 10). Our clinical judgement is that betahistine does have positive effects on vertigo, but that it is very hard to determine how great these effects are due to the immense number of poor studies and variable reviews concerning betahistine's efficacy.Ī case report by Strupp (2018) suggested that betahistine could be productively combined with seligiline (an MAO inhibitor) in very low doses. Tinnitus is not helped by Betahistine (Wegner et al, 2018) Rosenbaum and winter concluded that based on 12 trials, betahistine might be helpful, but the "certainty of evidence is low". Another Cochrane study from 2016 (Murdin et al), suggested that "Low quality evidence suggests that in patients suffering from vertigo from different causes there may be a positive effect of betahistine in terms of reduction in vertigo symptoms." A study of hydrops found that betahistine had no effect (Gurkov et al, 2012). It thus is similar in official status to an inert substance - think sawdust perhaps.īetahistine has been reviewed by the "Cochrane database" (see //cochrane/clsysrev/articles/CD001873/frame.html), who concluded in 2009 that "There is insufficient evidence to say whether betahistine has any effect on Ménière's disease". That Betahistine is harmful, but also little evidence that it has a therapeutic effect. Essentially, the conclusion was that there is no evidence This link has the text of the review (originally ). A recent exception is the study of Motamed et al (2017) where betahistine was found superior to promethazine.īetahistine was again reviewed by the FDA in June of 1999. Unfortunately, most of the studies of betahistine have major design failings - such as omitting a control group, or comparing betahistine to a homeopathic preparation. In Meniere's disease (James and Burton, 2001). Nevertheless, these studies may have been flawed and a review suggested that it is presently still unclear if betahistine has any effect Reduction of vertigo attacks with betahistine (Frew and Menon, 1976: WilmotĮt al, 2003). Subsequently, four double-blind studies have been done reporting Roughly 5 years, but later approval was withdrawn because lack of evidence forĮfficacy and because "the major report of effectiveness contained deficienciesĪnd misrepresentations" (Sampson, 2003). Curiously, Serc was approved by the US FDA about 50 years ago for This drug (brand name Serc, chemical name betahistine), is advocated as a vestibularĭisease. In 2005, Smith reported that 94% of the ENT surgeons in the United Kingdom prescribe betahistine to their Meniere's patients (Smith et al, 2005)
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |